ERBB2


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Related to ERBB2: ERBB3, HER2, EGFR

ERBB2

A gene on chromosome 17q11.2-q12 that encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 has no ligand-binding domain and thus cannot bind growth factors; it does, however, bind to other ligand-bound EGF receptor family members, forming a heterodimer, stabilising ligand binding and enhancing kinase-mediated activation of downstream signalling pathways (e.g., those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase).

Molecular pathology
ERBB2 amplification and overexpression commonly occurs in breast and ovarian cancers.
References in periodicals archive ?
Our review of the Catalogue of Somatic Mutations in Cancer (COSMIC) database identified the COSMIC identifier numbers of the following seven genes: EGFR (ENST00000275493), KRAS (ENST00000256078), PIK3CA (ENST00000263967), BRAF (ENST00000288602), ERBB2 (ENST00000269571), NRAS (ENST00000369535), and BIM (ENST_00000393256).
R175H in SKBR3) and gene amplifications (MYC in MCF-7, ZR-75-1, and SKBR3 and ERBB2 in SKBR3) in cell line DNA with a mean read depth of >2000X per sample (range 2177X to 2659X) (see online Supplemental Tables 4 and 5).
Heterogeneous amplification of ERBB2 in primary lesions is responsible for the discordant ERBB2 status of primary and metastatic lesions in gastric carcinoma.
The team then created mice in which the gene for ERBB2 was knocked out only in cardiomyocytes.
Examining ERBB2 as a candidate gene for susceptibility to leprosy (Hansen's disease) in Brazil.
Empleando el metodo de doble delta Ct, se calculo la dosis genica para c- MYC, MYCN, MYCL, EGFR, AKT-2, ERBB2, PIK3CA y c-REL para un panel de lineas celulares de origen tumoral pulmonar.
Further research is needed to confirm ERBB2's role in cetuximab resistance and to develop strategies for testing ERBB2 inhibitors in clinical trials.
The two genes that are being most widely studied as areas of uncontrolled replication are ERBB2 and CCND1.
To verify the kits, 1, 5,10, and 50 MDA-468 or the SKBR3 cells were directly spiked into lysis buffer followed by qualitative PCR amplifying EpCAM, EGFR, ERBB2, KRT19, and ACTB transcripts.
To investigate that targeting USP8 with its specific inhibitor might exhibit an anticancer effect in the corticotroph adenomas, we first examined the effect of USP8 inhibitor on downstream protein levels including EGFR, ERBB2, and Met.
Out of the darkness and into the light: bright field in situ hybridization for delineation of ERBB2 (HER2) status in breast cancer.