ETV1

(redirected from ER81)

ETV1

A gene on 7p21.3 that encodes a transcription activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.
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DGT), the La Jolla, California-based total gene expression company, today announced that scientists at the Mayo Foundation for Medical Education and Research will use DGT's patented TOGA(TM) gene expression profiling technology to investigate the role of the transcription factor ER81 in the formation of a variety of different tumors, including those associated with breast and ovarian cancer, as well as Ewing's sarcoma.
Janknecht's research will advance understanding of the role dysregulated transcription factors play in carcinogenesis, and accelerate the identification of those ER81 target genes which are suitable and novel targets for cancer therapy," said Brian S.
The ER81 protein is a DNA binding protein that regulates gene expression.
In addition, a chromosomal translocation can fuse the ER81 gene to the EWS (Ewing's sarcoma) gene, generating a constitutively active EWS-ER81 transcription factor.