EDEM3

(redirected from ER degradation enhancer, mannosidase alpha-like 3)

EDEM3

A gene on chromosome 1q25 that encodes an enzyme which accelerates endoplasmic reticulum-associated degradation (ERAD), extracting misfolded—but not productively folded—glycoproteins from the calnexin cycle and targeting them for degradation by proteasomes. It is thought to have mannosidase activity.