EDEM1

(redirected from ER degradation enhancer, mannosidase alpha-like 1)

EDEM1

A gene on chromosome 3p26.1 that encodes an enzyme directly involved in endoplasmic reticulum-associated degradation (ERAD), extracting misfolded—but not productively folded—glycoproteins from the calnexin cycle and targeting them for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It interacts with DERL2 and DERL3.