EPHX2


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EPHX2

A gene on chromosome 8p21 that encodes epoxide hydrolase-2. Epoxide hydrolases are critical biotransformation enzymes that activate and detoxify epoxides by breaking down aromatic compounds to dihydrodiols, which can be conjugated and excreted from the body.
 
Molecular pathology
EPHX2 mutations are associated with familial hypercholesterolaemia.
References in periodicals archive ?
SNPs in EPHX1, EPHX2, and CYP2E1 were significantly associated (unadjusted overall p-value < 0.
We identified significant associations between a priori-selected SNPs in EPHX1, EPHX2, and CYP2E1 and the frequency of MNBN lymphocytes (Table 4).
One of the strongest signs came from the gene EPHX2, which codes for epoxide hydrolase 2-an enzyme known to regulate cholesterol metabolism.
Among 498 SNPs associated with candidate genes, only 9 were located within exons {CYPJA2, ARNT2 (aryl-hydrocarbon receptor nuclear translocator 2), EPHX1 [epoxide hydrolase 1, microsomal (xenobiotic)], EPHX2, CYP26B1, GSTM3 (glutathione S-transferase mu 3 (brain)], and CYP4B11 and 87 were located within introns.