EPHX1


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EPHX1

A gene on chromosome 1q42.1 that encodes epoxide hydrolase-1. Epoxide hydrolases are critical biotransformation enzymes that activate and detoxify epoxides by breaking down aromatic compounds to dihydrodiols, which can be conjugated and excreted from the body.
 
Molecular pathology
EPHX1 mutations variously cause pre-eclampsia, epoxide hydrolase deficiency or increase epoxide hydrolase activity.
References in periodicals archive ?
Based on our microarray analysis, 14 genes, including three antimicrobial peptides (LEAP2, LOC396871, and MS4A2), two proteins involved in the regulation of proliferation and apoptosis of epithelial cells (PIAP and AREG), and genes associated with a number of physiological and metabolic processes (ATRN, CD59, CLU, DPEP1, EPHX1, RETN and UBP) were selected.
1 Dipeptidase DPEP1 NM_214108 Epoxide hydrolase NM_214355 EPHX1 Liver expressed NM_213788 antimicrobial peptide 2 LEAP2 Arginine rich antibacterial NM_214355.
SNPs in EPHX1, EPHX2, and CYP2E1 were significantly associated (unadjusted overall p-value < 0.
We identified significant associations between a priori-selected SNPs in EPHX1, EPHX2, and CYP2E1 and the frequency of MNBN lymphocytes (Table 4).
SNP Gene n MNBN (3) (mean [+ or -] SE) Rs1051741 EPHX1 424 GG 330 1.
In BAL cells of smokers, gene expression of EPHX1 and GSTP1 was significantly higher that that of nonsmokers, whereas expression of the UGT2A1 gene was significantly lower (p < 0.
Further, in BBs taken from smokers, expression of EPHX1 was significantly lower (p < 0.
For exposed persons, having GSTM1 and EPHX1 (epoxide hydrolase 1) genotypes conferring a lack of enzyme and less active enzyme, respectively, was shown to result in increased HCC risk (London et al.
1] Aflatoxin-albumin adducts CYP1A2 CYP3A4 HCC GSTM1 EPHX1 Heterocyclic amines Colon cancer NAT2 Breast cancer NAT2 SULT1A1 Aromatic amines Bladder cancer NAT2 (dye industry) Halomethanes Metabolite levels in GSTT1 blood Benzene Hematotoxicity CYP2E1 NQ01 Sister chromatid exchange GSTT1 in lymphocytes Halogenated solvents Renal cell carcinoma GSTT1 (e.