EPHX1

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EPHX1

A gene on chromosome 1q42.1 that encodes epoxide hydrolase-1. Epoxide hydrolases are critical biotransformation enzymes that activate and detoxify epoxides by breaking down aromatic compounds to dihydrodiols, which can be conjugated and excreted from the body.
 
Molecular pathology
EPHX1 mutations variously cause pre-eclampsia, epoxide hydrolase deficiency or increase epoxide hydrolase activity.
References in periodicals archive ?
A systematic approach to analyzing gene-gene interactions: polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1, GSTT1, and GSTP1 loci and breast cancer risk.
Influence of GSTM1, GSTT1, GSTP1, and EPHX gene polymorphisms on DNA adduct level and HPRT mutant frequency in coke-oven workers.
Influence of GSTM1, GSTT1, GSTP1 and EPHX gene polymorphisms on DNA adduct level and HPRT mutant frequency in coke-oven workers.