EPHA1

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EPHA1

A gene on chromosome 7q32-q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. It induces cell attachment to the extracellular matrix, inhibiting cell spreading and motility by regulating ILK and downstream RHOA and RAC. EPHA1 also plays a role in angiogenesis and cell proliferation, and may play a role in apoptosis. It is overexpressed in certain carcinomas.
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With the commencement of the CDC EPHT, the RIF was seen as a valuable tool that, with further enhancement, could be used more widely, such as in U.
The RIF is one of several tools that support EPHT work and is designed to complement already existing methods.
In defining a conceptual approach for EPHT, the CDC began with a model including the three elements: hazards, exposures, and diseases (Thacker et al.
Most pilot projects funded through EPHT demonstrate data linkages (CDC 2004b).
In 2005, the CDC selected four academic centers to participate in the next phase of the EPHT initiative and plans to competitively select state and local health departments for the next phase in 2006.
We have listed the goals and requirements for an EPHT system in Table 2.
The design of an EPHT and surveillance system cannot be static.
Initiation of linkage between existing disease and exposure surveillance systems for EPHT is very desirable and feasible.
For example, each program had ongoing collaborations with EPHT programs and reported channeling communications efforts through epidemiology or environmental health staff.
At a minimum, hazard data included in the national EPHT network will need to be obtained through routine standardized data collecting and reporting and must have ongoing quality control, appropriate geographic coverage for the population at risk, and be available in a timely manner.
EPHT limits itself to those health effects with scientific evidence of possible environmental etiology.
For example, IAQ is being assessed in approximately 100 schools as part of the MDPH's overall EPHT program.