EPHB4


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EPHB4

A gene on chromosome 7q22 that encodes a member of the ephrin-B receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. With its cognate ligand/functional ligand EFNB2, EPHB4 plays a central role in heart morphogenesis and angiogenesis by regulating cell adhesion and cell migration. EPHB4-mediated signalling controls cellular repulsion and segregation form EFNB2-expressing cells. EPHB4 also plays a role in postnatal blood vessel remodelling, morphogenesis and permeability, as occurs in tumour angiogenesis.
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This latest patent supports Molecular Health's discovery that EPHB4 is a novel receptor for Erythropoietin (EPO), where EPHB4 binds to EPO and promotes tumor growth.
Combined, Molecular Healthos multiple patents detail methods of determining whether a cancer patient is suitable for EPO therapy inter alia by identifying the level of expression of a novel erythropoietin receptor, EPHB4.