EPHA7

EPHA7

A gene on chromosome 6q16.1 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which “promiscuously” bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. EFNA5 is a cognate/functional ligand for EPHA7, and together they regulate brain development by modulating cell–cell adhesion and repulsion. EPHA7 has repellent activity on axons and is involved in guiding corticothalamic axons (and, in the proper topographic mapping, retinal axons) to the colliculus. It may also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signalling may result in activation of components of the ERK signalling pathway, including MAP2K1, MAP2K2, MAPK1 and MAPK3, which are phosphorylated in response to EPHA7 activation.
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Symbol Entrez gene name WNT16 Wingless-type MMTV integration site family, member 16 PLCD4 Phospholipase C, delta 4 ADAM29 ADAM metallopeptidase domain 29 MMP8 Matrix metallopeptidase 8 (neutrophil collagenase) EPHA6 EPH receptor A6 PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 EPHA7 EPH receptor A7 EPHA3 EPH receptor A3 SEMA6D Serna domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D ADAM30 ADAM metallopeptidase domain 30 UNC5D Unc-5 homolog D (C.