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EPHA1A gene on chromosome 7q32-q36 that encodes a member of the ephrin-A receptor subfamily of receptor tyrosine kinases, which promiscuously bind membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signalling into neighbouring cells. It induces cell attachment to the extracellular matrix, inhibiting cell spreading and motility by regulating ILK and downstream RHOA and RAC. EPHA1 also plays a role in angiogenesis and cell proliferation, and may play a role in apoptosis. It is overexpressed in certain carcinomas.
Patient discussion about EPH
Q. after a pedicure, the soles of my feet are dark w/freckles, skin is itchy/thick, my derm says its eczema,help! the pedicure was in fall, 2002. I mad a mistake and wore nylon boots during a storm, the dye never fully disappeared. I would scrub the soles of my feet until I couldn't walk. However, within the last 4 months both heels are itchy, thick, dark-er and now they both have dark legions/ freckles have formed.