EPCAM


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EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
By analyzing CTC in our patient cohort, according to Adnatest OvarianCancer, we demonstrated that positivity of at least one of the tumor-associated transcripts EPCAM, MUC1, or MUC16 in the patient's blood was associated with decreased OS, consistent with our previous observation (21).
Many cases may be positive for EPCAM and CA19-9, which are also positive in a high percentage of pancreatic mucin-producing neoplasms and DADCs.
cerevisiae); EPCAM, epithelial cell adhesion molecule; BRAF (v-raf murine sarcoma viral oncogene homolog B; PMS2CL, PMS2 C-terminal like pseudogene.
cerevisiae)]--as well as germline deletions of EPCAM (epithelial cell adhesion molecule) that produce transcriptional read-through leading to hypermethylation of the MSH2 promoter, which is located adjacent to EPCAM on chromosome 2p21.