TMPRSS15

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TMPRSS15

A gene on chromosome 21q21 that encodes a serine protease responsible for activating pancreatic proteolytic proenzymes by catalysing the conversion of trypsinogen to trypsin, which in turn activates other proenzymes, including chymotrypsinogen, procarboxypeptidases and proelastases. It is localised at the intestinal brush border.

Molecular pathology
Defects in TMPRSS15 are a cause of enterokinase deficiency.