ELP4

ELP4

A gene on chromosome 11p13 that encodes a widely expressed protein which acts as a subunit of the RNA polymerase-II elongator complex, a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme involved in transcriptional elongation. The elongator complex acetylates histone H3 and possibly also H4, and it may play a role in chromatin remodelling.
References in periodicals archive ?
While comparing this region in people with Rolandic epilepsy to unaffected controls, the researchers pinpointed the gene, called ELP4.
ELP4 has never before been linked to a human disease but is related to a group of genes (transcriptional regulators) that recently have been associated with other common forms of epilepsy.