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MiR-143 has been proved to have an anti-cancer effect by targeting multiple genes related to cell proliferation, apoptosis and migration, such as Bcl-2 (13), MYO6 (14), ELK1 (15), and ERK5 (16).
The ERK signaling pathway involves an additional protein, ELK1 which interacts with ERK2 to activate the genetic information.
However, at 20h after infection, AKT2, ELK1, c-Jun, c-Fos, NF-[kappa]B p65, PI3K and STAT1 in EV71-infected RD cells were up-regulated and exhibited 2.