EIF2A

EIF2A

A gene on chromosome 3q25.1 that encodes a widely expressed protein involved in early protein synthesis of a limited number of specific mRNAs, directing the binding of methionyl-tRNAi to 40S ribosomal subunits.
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These genes include a) components of the RNAP II general transcription machinery (RPB8, RPB10, TAF10; Figure 5A); b) transcription termination and polyadenylation factors (NSAP1; Figure 5A); c) mRNA splicing factors (SFPQ, U2AF1, RNPS1; Figure 5A); d) mRNA export proteins (NXF1; Figure 5C); e) protein translation factors (EIF1A, EIF2A, EIF2B, EIF3; ribosomal proteins RPL11, RPL12, RPL20, RPL52, RPS18b, and tRNA synthetases VALRS, GLURS, PHERS; Figure 5D), and f) protein folding factors (FKBP4, CCT3, CCT6a, CCT7, CCT8; Figure 5E).