EPCAM

(redirected from EGP40)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
SFD is seeking to sign two contracts with Housing and Development Bank (HDB) worth EGP60 million and it divided into one contract with EGP40 million and the other with EGP20 million, along with Societe Arabe Internationale de Banque (SAIB)'s contract with EGP60 million.
The administrative court fined Mubarak EGP200 million, former Prime Minister Ahmed Nazif EGP40 million, and former Interior Minister Habib al-Adli EGP300 million, the report added.
Salman went on to say that "energy borrowing for the public business sector now exceeds EGP40 billion", explaining that he believes the asset management company will contribute to financing solutions for companies.