EPCAM

(redirected from EGP314)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
The head of the Central Agency for Reconstruction said that the total cost of investment in Giza Government is EGP4 bn and EGP314 m including the expropriation works and transfer of squires required for the construction of Rawd Al Faraj axis at a cost of EGP 2 bn and EGP 400 m.
24 carat gold increased to EGP320 per gram, compared to EGP314 on Monday, while the price of a pound of gold increased EGP50 from EGP2210 on Monday to EGP2260 on Tuesday.