EPCAM

(redirected from EGP3)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
Investments for Ashgar City will be about EGP3 billion ($392 million), Bahaa said.
This pharmacy, which cost approximately EGP3 million ($541,077) to 3.
Bejjani also unveiled two new projects forming part of the original EGP18 billion investment plan, including a new City Centre, under the name of City Centre Almaza, with investments of EGP3.
Galal and the Minister of Industry and Foreign Trade further discussed ways to help develop and simplify the country's export process, with plans to disburse EGP3.
In Q410, the Egyptian government launched a tender for licences to produce 3mn tonnes of steel, requiring investments worth EGP3.