FABP5

(redirected from EFABP)

FABP5

A gene on chromosome 8q21.13 that encodes a lipid transport protein in epidermal cells which may be involved in keratinocyte differentiation. FABP5 binds fatty acids and has the highest affinity for C18 length chains; it is upregulated in psoriasis.
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We assayed adiponectin in whole milk and leptin, AFABP, and EFABP in skim milk.
The assay has no detectable cross-reactivity to human EFABP, HFABP, IFABP, LFABP, leptin, leptin receptor, adiponectin, resistin, RELM-(3 at 100.
The protein content was determined by the Bradford method (Sigma-Aldrich) with recombinant EFABP (Biovendor) with >95% purity confirmed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (data not shown) as a calibrator, prepared at concentrations of 40, 20, 10, 5, 2, and 1 [micro]g/L in 5% BSA (w/v) in TBS-Tw and 100 [micro]L directly pippeted into the wells.
The specificity of the immunoassay was confirmed by reactivity with recombinant EFABP (Abnova).
Skim breast milk samples from 2 participants with baseline EFABP concentrations of 5.
There was no relationship with the number of previous pregnancies or deliveries or any other variable in mothers or newborns, nor with AFABP, EFABP, or leptin milk concentrations.
We found a strong positive correlation between AFABP and EFABP (r = 0.
Mean (SE) EFABP breast milk concentrations (n = 57) were 18.
We demonstrated, for the first time, the presence of adiponectin, AFABP, and EFABP in human breast milk.
Birth weight correlated positively with EFABP concentrations in breast milk.
We found a positive correlation between AFABP and EFABP rather than a compensatory regulation as reported in adipose tissue (36), indicating an important role for EFABP.
We demonstrated significantly higher EFABP concentrations in breast milk of mothers who delivered boys, but when we corrected for body weight regardless of sex we found that the positive correlation between EFABP concentrations and the body weight of newborns was not related to sex but to higher body weight in boys.