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EDRF |
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EDRF, abbreviation for endothelial-derived relaxing factor, a term which is now used synonymously with nitric oxide. EDRF endothelium-derived relaxing factor. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Nitric oxide is a biogenic messenger, an EDRF (15,16), and it activates the guanylyl cyclase system (17) [it converts guanosine triphosphate to cyclic guanosine monophosphate (cGMP)], raising the cGMP pool and therefore inducing, among other things, vasodilatation (17) by lowering the intracellular calcium ion (16). Ignarro and Chaudhuri together showed that EDRF was definitely nitric oxide. Since the accidental discovery, in 1980, of the important role the vascular endothelium plays in the regulation of vascular smooth muscle tone,[82] the identification of endothelium-derived relaxing factor (EDRF) in 1982,[83] and the discovery in 1986 that EDRF was indistinguishable from nitric oxide (NO),[84,85] numerous articles regarding the actions and effects of NO have been published. |
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