EDEM3

EDEM3

A gene on chromosome 1q25 that encodes an enzyme which accelerates endoplasmic reticulum-associated degradation (ERAD), extracting misfolded—but not productively folded—glycoproteins from the calnexin cycle and targeting them for degradation by proteasomes. It is thought to have mannosidase activity.
References in periodicals archive ?
When trimming of an outermost Man residue occurs on the C-arm of high mannose-type glycans by EDEM1 or EDEM3, it binds OS-9 and XTP3-B.