FGFR2

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FGFR2

A gene on chromosome 10q25.3-q26 that encodes fibroblast growth factor receptor-3, which has an extracellular region composed of 3 immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Binding of a ligand unleashes a cascade of downstream signals that impact on mitogenesis and differentiation.

Molecular pathology
FGFR3 mutations are associated with Apert syndrome, Beare-Stevenson cutis gyrata syndrome, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome and syndromic craniosynostosis.
References in periodicals archive ?
ECT1 Transactions on Computer and Information Technology, 2(2): 126-134.
Exclusion of dm1 makes the sign of ECT1 positive despite the satisfactory rank test results.
TABLE 10 VEC Model for the Five GCC Indices in the GCC - 5 VAR, 2/15/1994-12/25/2001 LBSEI(-1) LKSEI(-1) LMSMI(-1) LBSEI(-2) LKSEI(-2) LMSMI(-2) ECT1 LBSEI(-3) LKSEI(-3) LMSMI(-3) Model ECT2 LBSEI(-4) LKSEI(-4) LMSMI(-4) LBSEI 0.