ALG12

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ALG12

A gene on chromosome 11q14.1 that encodes a member of the glycosyltransferase 22 family which catalyses the addition of the 8th mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)), which is required for protein glycosylation.
 
Molecular pathology
ALG12 is mutated in congenital disorder of glycosylation type Ig (CDGIg).