EB simplex

EB simplex

; Weber-Cockayne EB non-scarring blistering at basal layer of epidermis, often affecting palmar/plantar or other areas of easily traumatized skin, and worse in summer weather
  • dystrophic EB severe scar-inducing blistering at lower levels of dermoepidermal junction; onset during infancy, with a relentlessly progressive course causing marked scarring in response to minor trauma, fusion and resorption of fingers and toes, growth retardation, anaemia and oesophageal strictures

  • junctional EB scar-inducing blistering at upper levels of dermoepidermal junction

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At least 27 different types of EB have been described, but the three main forms are EB simplex, Dystrophic EB and Junctional EB.
For example, in the commonest form EB simplex, blistering is usually limited to the hands and feet, but it may occur all over the body.
EB simplex may first appear in the newborn period or later in childhood, or even adult life.
Tony has a form of EB simplex known as Dowling-Meara, which varies in severity.
EB can be divided into three main types ( EB simplex, junctional EB and dystrophic EB.
Approximately 70% of people with EB suffer from EB simplex, the most common form of which is blistering confined to hands and feet.
Epstein at the University of California, San Francisco, found a similar type of keratin mutation in one family with 10 EB simplex patients.
Two of the new reports focus on EB simplex, blaming it on a genetic defect in keratin -- the key protein in the springy "inner skeletons" of cells.
There are four major type of inherited epidermolysis bullosa: EB simplex (EBS), junctional EB (JEB), dystrophic EB (DEB) and Kindler syndrome.
Treatment can include simple things like avoiding triggering factors such as walking for long distances in warm weather, which causes blistering on the soles of the feet in EB Simplex.
Two out of three sufferers have EB simplex, which affects hands and feet.