SLC1A1(redirected from EAAT3)
SLC1A1A gene on chromosome 9p24 that encodes solute carrier family 1 member 1, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters terminate the postsynaptic action of the neurotransmitter glutamate and maintain extracellular glutamate concentrations below neurotoxic levels. SLC1A1 also transports aspartate.
SLC1A1 loss-of-function mutations cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect.