NFIL3

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NFIL3

A gene on chromosome 9q22 that encodes a transcription regulator that binds to regulatory regions of genes, usually upstream of a transcription start site, primarily downregulating transcription from promoters with activating transcription factor (ATF) sites. NFIL3 is thought to repress promoter activity in osteoblasts, transcription of PER1, and of PER2 via the promoter’s B-site. It activates transcription from the interleukin-3 promoter in T-cells, competes with PAR DNA-binding factors (DBP) HLF and TEF for the consensus-binding site, acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous clock and protects pro-B cells from apoptosis.