E2F5

E2F5

A gene on chromosome 8q21.2 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F5 binds to tumour suppressor proteins p107 and p130, but not to retinoblastoma protein pRB.
References in periodicals archive ?
Triptolide downregulated the cell cycle-related genes E2F2 E2F3, E2F5, CDKN2C, CDK7, CDC23, and SMAD3; the MAPK signaling pathway genes FOS, CASP3, JUND, KRAS, MAP2K2; and the Wnt signaling pathway genes WNT4, MYC, and AXIN2.