E2F4

E2F4

A gene on chromosome 16q21-q22 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F4 binds to tumour suppressor proteins p107 and p130, and also (though with less affinity) to retinoblastoma protein pRB.
References in periodicals archive ?
RB and E2F4 have been shown necessary for erythroid maturation in knockout mice, suggesting a partial mechanism for the cyclopamine-induced delay of erythroid maturation.