E2F4

E2F4

A gene on chromosome 16q21-q22 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F4 binds to tumour suppressor proteins p107 and p130, and also (though with less affinity) to retinoblastoma protein pRB.
References in periodicals archive ?
E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin.
326,327) Accumulation of MSI in growth regulatory and tumor suppressor genes, such as the Bloom syndrome helicase gene, the proapoptotic BAX gene, PTEN, and the E2F4 transcription factor involved in cell cycle control, is then thought to drive tumorigenesis.
RB and E2F4 have been shown necessary for erythroid maturation in knockout mice, suggesting a partial mechanism for the cyclopamine-induced delay of erythroid maturation.