E2F3

E2F3

A gene on chromosome 6p22 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F3 binds specifically to the tumour suppressor retinoblastoma protein pRB in a cell-cycle-dependent manner.
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Lakshman Varanassi, UMMC E2F3 and the DNA damage response: How genomics enables discovery 2.
On the other hand, the non-ischemic wounds on the mice showed abundant levels of the E2F3 protein and healed normally within about seven days.
The Checkerboard Tissue Microarray (TMA) Method, developed by scientists at the Institute of Cancer Research, looks for the multiple markers of various genes associated with prostate cancer - including the E2F3 gene.
The test, which can be carried out on prostate cancer biopsies, looks for various genes associated with the disease including the E2F3 gene.
They found there was an over- expression of E2F3 in the cancer cells and that the more E2F3 was present, the worse the prognosis was for the patient.
Professor Chris Foster from Liverpool University claims the E2F3 gene will help doctors predict how aggressive the cancer will be and decide what treatment to give.
Scientists now hope that by using the E2F3 gene as a marker of how aggressive the prostate tumour is, a long sought after test to distinguish between aggressive and non- aggressive cancer cells will become a reality.
Additionally, they noted that the amount of E2F3 proteins present was a significant indicator of the seriousness of the cancer.
E2F3 amplification and overexpression is associated with invasive tumor growth and rapid tumor cell proliferation in urinary bladder cancer.
Triptolide downregulated the cell cycle-related genes E2F2 E2F3, E2F5, CDKN2C, CDK7, CDC23, and SMAD3; the MAPK signaling pathway genes FOS, CASP3, JUND, KRAS, MAP2K2; and the Wnt signaling pathway genes WNT4, MYC, and AXIN2.
The newly-identified gene, E2F3, produces a protein which plays a key role in promoting cell division in all human cells.
E2F3 is the missing link in our knowledge of this disease.