E2F2

E2F2

A gene on chromosome 1p36 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F2 binds specifically to the tumour suppressor retinoblastoma protein pRB in a cell-cycle-dependent manner.
References in periodicals archive ?
Modeling time-dependent transcription effects of HER2 oncogene and discovery of a role for E2F2 in breast cancer cell-matrix adhesion, Bioinformatics 30(21): 3036-3043.
Specifically, Andrechek's team found the activation of the specific gene E2F2 was associated with a higher probability of breast cancer relapse in humans.
A representation of the polymorphism distribution and gene structure of E2F2 is shown in Figure 2, and each of the candidate genes being examined by the EGP is available in a similar format via the GeneSNPs database (http://genome.
Expression of several genes appeared to be down regulated, including FOXM1 , thought to be a direct target of hedgehog signaling; K167, function unkown; and Retinoblastoma (RB), E2F2, and E2F4.
Triptolide downregulated the cell cycle-related genes E2F2 E2F3, E2F5, CDKN2C, CDK7, CDC23, and SMAD3; the MAPK signaling pathway genes FOS, CASP3, JUND, KRAS, MAP2K2; and the Wnt signaling pathway genes WNT4, MYC, and AXIN2.
This was followed by the 0-s delay condition, in which the ED training and EF training required the successive correct completion of seven randomly intermixed trials of each type (E1D1, E2D2, E3D3, E1F1, E2F2, and E3F3) before testing.