E2F4

(redirected from E2F transcription factor 4, p107/p130-binding)

E2F4

A gene on chromosome 16q21-q22 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F4 binds to tumour suppressor proteins p107 and p130, and also (though with less affinity) to retinoblastoma protein pRB.