E2F3

(redirected from E2F transcription factor 3)

E2F3

A gene on chromosome 6p22 that encodes a member of the E2F family of DNA-binding transcription factors, which play a key role in regulating the cell cycle and tumour suppressor proteins. E2F3 binds specifically to the tumour suppressor retinoblastoma protein pRB in a cell-cycle-dependent manner.