UBE2B

(redirected from E2 protein)

UBE2B

A gene on chromosome 5q31.1 that encodes a member of the E2 ubiquitin-conjugating enzyme family required for post-replicative DNA damage repair.
References in periodicals archive ?
Moreover it was also in accordance with another study by Hsieh et al, in which mRNA levels were not altered by HCV E2 protein however IRS-1 protein level was reduced17.
Any successful hepatitis C vaccine is likely to target the E2 protein.
BVDV E2 protein and the viral RNA level were determined by immunofluorescence and quantitative real-time RT-PCR, respectively.
The E2 protein has the binding sites for human CD81, a tetraspanin expressed on various cell types including hepatocytes and B lymphocytes (45).
Studies of [epsilon]2/[epsilon]4 heterozygotes have revealed that the E4 protein isoform is catabolized from all lipoprotein fractions ~3-fold faster than the E2 protein isoform (14), whereas E3 is catabolized at an intermediate rate (15-17).
Detection of pestivirus E2 protein with monoclonal antibody 6A5 in investigation of piglets with congenital tremor (CT) on a farm in southeastern Austria, 2015.
It was shown that HPV encoded E2 protein is localized predominantly in the nucleus of infected cells.
The E2 protein of HGV-C/HGV on the other hand has limited glycosylation and lacks a hypervariable region probably accounting for the higher rate of viral clearance as compared to HCV.
Genetic analysis of CHIKV genomes has shown substitutions in envelope (E) 1 and E2 proteins that affect virus adaptability to Aedes mosquitoes.
E2-25K/Hip2 seems to function both as an E2 ubiquitin-conjugating enzyme like other E2 proteins and as an unusual ubiquitin ligase to produce diubiquitin and unanchored polyubiquitin chains without any E3 ligase [80].