UBE2B

(redirected from E2 protein)

UBE2B

A gene on chromosome 5q31.1 that encodes a member of the E2 ubiquitin-conjugating enzyme family required for post-replicative DNA damage repair.
References in periodicals archive ?
Any successful hepatitis C vaccine is likely to target the E2 protein.
Usually if you try to express the E2 protein in cultured cells, you either can't express it in useful quantities or you can but it aggregates and becomes a big mess," lead author Leopold Kong, a research associate in the Wilson laboratory, said.
The most stable inhibitor was then tested in mammalian cells and was found to inhibit the E2 protein of HPV-16, the high-risk strain that is most commonly associated with cancers.
Design and characterization of an enhanced repressor of human papillomavirus E2 protein.
BVDV E2 protein and the viral RNA level were determined by immunofluorescence and quantitative real-time RT-PCR, respectively.
The E2 protein has the binding sites for human CD81, a tetraspanin expressed on various cell types including hepatocytes and B lymphocytes (45).
Studies of [epsilon]2/[epsilon]4 heterozygotes have revealed that the E4 protein isoform is catabolized from all lipoprotein fractions ~3-fold faster than the E2 protein isoform (14), whereas E3 is catabolized at an intermediate rate (15-17).
In laboratory tests, binding of this antibody to the E2 protein was shown to potently inhibit binding of E2 to Hepatitis C virus-susceptible cells.
The E2 protein of HGV-C/HGV on the other hand has limited glycosylation and lacks a hypervariable region probably accounting for the higher rate of viral clearance as compared to HCV.
antibody reacts with the E2 protein, which is expressed on the surface
In contrast, the E1 and E2 proteins represent excellent therapeutic targets in both mucosal and cutaneous HPV infections.
7,316,908--'PEPTIDES FROM THE E2 PROTEINS OF HUMAN PAPILLOMAVIRUSES 16 AND 18 FOR DETECTING AND/OR DIAGNOSING CERVICAL AND OTHER HUMAN PAPILLOMAVIRUS-ASSOCIATED CANCERS--has issued to the Company.