ETV4

(redirected from E1AF)

ETV4

A gene on 17q21 that encodes a transcription activator that binds to the adenovirus E1A gene enhancer, specifically at the core-binding sequence 5'[AC]GGA[AT]GT-3'.
References in periodicals archive ?
23) Less-common cytogenetic variants, however, have also been identified and are characterized by the fusion of the EWSR1 gene with other members of the ETS family of transcription factors, including ERG (21q22), ETV1 (7p22), E1AF (17q21), and FEV (2q35-36).
39) Other variant translocations reported in bone EFT accounting for less than 1% of cases include t(7;22)(p22; q12), t(17;22)(q12;q12), and t(2;22)(q23;q12), involving fusion of EWS to ETV1, E1AF, and FEV genes, respectively (Table 2).
Fusion of an ETS-family gene, E1AF, to EWS by t(7;22)(q12;q12) chromosome translocation in an undifferentiated sarcoma of infancy.