CCHFV belongs to the genus Nairovirus (family Bunyaviridae), which contains 7 serogroups: CCHFV, Dugbe virus
, Hughes virus, Sakhalin virus, Dera Ghazi Khan virus, Qalyub virus, and Thiafora virus.
The important members of the genus Nairovirus include CCHFV, NSDV, in addition to GANV, HAZV and Dugbe virus (DUGV).
Pathogenesis of Dugbe virus infection in wild- type and interferon-deficient mice.
Crimean-Congo haemorrhagic fever virusun de icinde bulundugu Nairovirus grubu, toplam yedi farkli serogrup virus tarafindan olusturulur (Crimean-Congo haemorrhagic fever virus, Dera Ghazi Khan virus, Dugbe virus
, Hughes virus, Qalyub virus, Sakhalin virus ve Thiafora virus).
variegatum ticks may transmit other human and animal pathogens, including Crimean-Congo hemorrhagic fever virus, Dugbe virus
, Thogoto virus, Bhanja virus, Ehrlichia ruminantium, Theileria spp.
We have previously described isolation and preliminary identification of a virus related to Dugbe virus (DUGV), family Bunyaviridae, genus Nairovirus.
Full-length sequence data are now available for CCHFV, Hazara virus (HAZV) and Dugbe virus (DUGV), and partial sequences are available for many other members of the genus.
As expected from this data, phylogenetic analysis of full-length L segment aa sequence resulted in a tree showing Kupe virus more closely related to Dugbe virus than in the S or M segment trees (Figure 2, panel C).
Cross-reactivity was excluded by testing DNA or RNA from cultures or high-titered clinical samples containing Dugbe virus
, Rift Valley fever virus, Sudan Ebolavirus Gulu, Lassa virus AV, yellow fever virus, dengue virus types 1-4, Japanese encephalitis virus, West Nile virus Uganda, Venezuelan equine encephalitis virus, Sindbis virus, Ross River virus, Epstein-Barr virus, hepatitis C virus, human cytomegalovirus, monkeypox virus, poliomyelitis virus types 1-3, rabies virus RSDD Bacillus anthracis, Leptospira interrogans, Listeria monocytogenes, Neisseria meningitidis, Coxiella burnetii, Rickettsia prowazekii, R.
Virus isolates included Dugbe virus (DUGV), an unknown virus related to DUGV, Thogoto, Bhanja, Kadam, Dhori, Barur, and foot-and-mouth disease (FMDV) viruses.
Dugbe virus (DUGV), another member of the Nairovirus genus, has been repeatedly confirmed in tickborne virus surveys in Africa and causes febrile illness and thrombocytopenia in humans (2).
CCHFV shares some common antigenic and genetic properties with Dugbe virus
(DUGV), another member of the genus Nairovirus; some G1 epitopes may be conserved between the two viruses.