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xeroderma |
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xeroderma /xe·ro·der·ma/ (zer?o-der´mah) a mild form of ichthyosis, marked by a dry, rough, discolored state of the skin.xerodermat´ic xeroderma pigmento´sum a rare pigmentary and atrophic autosomal recessive disease in which extreme cutaneous sensitivity to ultraviolet light results from an enzyme deficiency in the repair of DNA damaged by ultraviolet light. It begins in childhood, with early development of excessive freckling, telangiectases, keratomas, papillomas, and malignancies in sun-exposed skin, severe opthalmologic abnormalities, and, in some cases, neurological disorders.
xeroderma, n a chronic skin condition characterized by dryness and roughness. xeroderma pigmentosum, n an eruption of exposed skin occurring in childhood and characterized by numerous pigmental spots resembling freckles, larger atrophic lesions eventually resulting in glossy white thinning of the skin surrounded by telangiectases, and multiple solar keratoses that undergo malignant changes at an early age. This results from a single-gene autosomal recessive disorder. xeroderma a mild form of ichthyosis; excessive dryness of the skin. |
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