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drug-drug interaction

   Also found in: Acronyms, Wikipedia 0.01 sec.
drug-drug interaction,
a modification of the effect of a drug when administered with another drug. The effect may be an increase or a decrease in the action of either substance, or it may be an adverse effect that is not normally associated with either drug. The particular interaction may be the result of a chemical-physical incompatibility of the two drugs or a change in the rate of absorption or the quantity absorbed in the body, the binding ability of either drug, or an alteration in the ability of receptor sites and cell membranes to bind either drug. Most adverse drug-drug interactions are either pharmacodynamic or pharmacokinetic in nature.


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Based on CORINA-generated 3D structures, the predictions of StarDrop's P450 metabolism models assist scientists to selectively redesign molecules in order to overcome possible metabolism problems or drug-drug interactions.
Included are discussions of PXR and XAR as xenobiotic receptors, their structure and function, animal models, drug-drug interactions of prescription drugs and herbal medicines, and genetic variants.
About 2 million individuals are potentially at risk for a major drug-drug interaction, according to a study of about 3000 people published in the Journal of the American Medical Association (JAMA) in early January.
 
 
 
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