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intolerance |
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intolerance /in·tol·er·ance/ (in-tol´er-ans) inability to withstand or consume; inability to absorb or metabolize nutrients. congenital lysine intolerance an inherited disorder due to a defect in the degradation of lysine, characterized by vomiting, rigidity, and coma, and high levels of ammonia, lysine, and arginine in the blood. congenital sucrose intolerance a disaccharide intolerance specific for sucrase, usually due to a congenital defect in the sucrase-isomaltase enzyme complex; see sucrase-isomaltase deficiency. disaccharide intolerance a complex of abdominal symptoms after ingestion of normal quantities of dietary carbohydrates, including diarrhea, flatulence, distention, and pain; it is usually due to deficiency of one or more disaccharidases but may be due to impaired absorption or other causes. drug intolerance 1. inability to continue taking, or difficulty in continuing to take, a medication because of an adverse side effect that is not immunity-mediated. 2. the state of reacting to the normal pharmacologic doses of a drug with the symptoms of overdosage. hereditary fructose intolerance an inherited disorder of fructose metabolism due to an enzymatic deficiency, with onset in infancy, characterized by hypoglycemia with variable manifestations of fructosuria, fructosemia, anorexia, vomiting, failure to thrive, jaundice, splenomegaly, and an aversion to fructose-containing foods. lactose intolerance a disaccharide intolerance specific for lactose, usually due to an inherited deficiency of lactase activity in the intestinal mucosa, which may not be manifest until adulthood. Congenital lactose i. may be due to an inherited immediate deficiency of lactase activity or may be a more severe disorder with vomiting, dehydration, failure to thrive, disacchariduria, and cataracts, probably due to abnormal permeability of the gastric mucosa. lysinuric protein intolerance a hereditary disorder of metabolism involving a defect in dibasic amino acid transport; characterized by growth retardation, episodic hyperammonemia, seizures, mental retardation, hepatomegaly, muscle weakness, and osteopenia; it can be treated with citrulline supplementation.
intolerance, n undesirable response to a substance (i.e., food, allergen, or remedy) or conditions. See also aggravation, idiosyncrasy, and tolerance. intolerance, n inability to endure or withstand. intolerance inability to withstand or consume; inability to absorb or metabolize nutrients. drug intolerance the state of reacting to the normal pharmacological doses of a drug with the signs of overdosage. |
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| Among adults, the test patients are the motivated ones, says Marlowe -- people with drug intolerance or poor lung function that would make chemical anesthesia dangerous, or people who are emotionally upset at the idea of anesthesia. Puricase was administered by subcutaneous injection in the first study, which resulted in injection site reactions and drug intolerance in some patients. The drug appeared to be well tolerated, with only five patients discontinuing treatment due to drug intolerance. |
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