intolerance (redirected from Drug intolerance)

intolerance /in·tol·er·ance/ (in-tol´er-ans) inability to withstand or consume; inability to absorb or metabolize nutrients.

---

congenital lysine intolerance  an inherited disorder due to a defect in the degradation of lysine, characterized by vomiting, rigidity, and coma, and high levels of ammonia, lysine, and arginine in the blood.

congenital sucrose intolerance  a disaccharide intolerance specific for sucrase, usually due to a congenital defect in the sucrase-isomaltase enzyme complex; see sucrase-isomaltase deficiency.

disaccharide intolerance  a complex of abdominal symptoms after ingestion of normal quantities of dietary carbohydrates, including diarrhea, flatulence, distention, and pain; it is usually due to deficiency of one or more disaccharidases but may be due to impaired absorption or other causes.

drug intolerance 

1. inability to continue taking, or difficulty in continuing to take, a medication because of an adverse side effect that is not immunity-mediated.

2. the state of reacting to the normal pharmacologic doses of a drug with the symptoms of overdosage.

hereditary fructose intolerance  an inherited disorder of fructose metabolism due to an enzymatic deficiency, with onset in infancy, characterized by hypoglycemia with variable manifestations of fructosuria, fructosemia, anorexia, vomiting, failure to thrive, jaundice, splenomegaly, and an aversion to fructose-containing foods.

lactose intolerance  a disaccharide intolerance specific for lactose, usually due to an inherited deficiency of lactase activity in the intestinal mucosa, which may not be manifest until adulthood. Congenital lactose i. may be due to an inherited immediate deficiency of lactase activity or may be a more severe disorder with vomiting, dehydration, failure to thrive, disacchariduria, and cataracts, probably due to abnormal permeability of the gastric mucosa.

lysinuric protein intolerance  a hereditary disorder of metabolism involving a defect in dibasic amino acid transport; characterized by growth retardation, episodic hyperammonemia, seizures, mental retardation, hepatomegaly, muscle weakness, and osteopenia; it can be treated with citrulline supplementation.

---

in·tol·er·ance (n-tlr-ns)

n.

Extreme sensitivity or allergy to a drug, food, or other substance.

---

in·toler·ant adj.

---

intolerance,

n undesirable response to a substance (i.e., food, allergen, or remedy) or conditions. See also aggravation, idiosyncrasy, and tolerance.

---

intolerance,

n inability to endure or withstand.

---

intolerance

inability to withstand or consume; inability to absorb or metabolize nutrients.

---

drug intolerance

the state of reacting to the normal pharmacological doses of a drug with the signs of overdosage.