Dramamine


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Dramamine

 [dram´ah-mēn]
trademark for preparations of dimenhydrinate or meclizine hydrochloride, antihistamines effective against nausea and vomiting, especially in motion sickness, and vertigo.

dimenhydrinate

Apo-Dimenhydrinate (CA), Arlevert (UK), Dramamine, Dramanate (CA), Gravol (CA), PMS-Dimenhydrinate (CA), Travamine (CA), TripTone

Pharmacologic class: Anticholinergic

Therapeutic class: Antiemetic, antivertigo agent

Pregnancy risk category B

Action

Prevents nausea and vomiting by inhibiting vestibular stimulation of chemoreceptor trigger zone and inhibiting stimulation of vomiting center in brain

Availability

Injection: 50 mg/ml

Tablets: 50 mg

Tablets (chewable): 50 mg

Indications and dosages

Prevention and treatment of nausea, vomiting, dizziness, and vertigo

Adults and children ages 12 and older: 50 to 100 mg P.O. q 4 hours (not to exceed 400 mg/day), or 50 mg I.M. or I.V. q 4 hours p.r.n.

Children ages 6 to 12: 25 to 50 mg P.O. q 6 to 8 hours (not to exceed 150 mg/day), or 1.25 mg/kg I.M. (37.5 mg/m2) q 6 hours p.r.n.

Children ages 2 to 6: 12.5 to 25 mg P.O. q 6 to 8 hours (not to exceed 75 mg/day)

Contraindications

• Hypersensitivity to drug or tartrazine
• Alcohol intolerance

Precautions

Use cautiously in:
• angle-closure glaucoma, seizure disorders, prostatic hypertrophy
• children younger than age 2.

Administration

• For I.V. use, dilute with dextrose 5% in water or normal saline solution.
• Give each 50-mg I.V. dose over 2 minutes.

Don't administer by I.V. route to premature or low-birth-weight infants. Solution contains benzyl alcohol, which can cause fatal "gasping" syndrome.

Adverse reactions

CNS: drowsiness, dizziness, headache, paradoxical stimulation (in children)

CV: hypotension, palpitations

EENT: blurred vision, tinnitus

GI: diarrhea, constipation, dry mouth

GU: dysuria, urinary frequency

Skin: photosensitivity

Other: decreased appetite, pain at I.M. site

Interactions

Drug-drug.Disopyramide, quinidine, tricyclic antidepressants: increased anticholinergic effects

MAO inhibitors: intensified and prolonged anticholinergic effects

Other CNS depressants (such as antihistamines, opioids, sedative-hypnotics): additive CNS depression

Ototoxic drugs (such as aminoglycosides, ethacrynic acid): masking of signs or symptoms of ototoxicity

Drug-diagnostic tests.Allergy skin tests: false-negative results

Drug-behaviors.Alcohol use: increased CNS depression

Patient monitoring

• Assess for lethargy and drowsiness.
• Monitor for dizziness, nausea, and vomiting (possible indicators of drug toxicity).

Patient teaching

• To prevent motion sickness, advise patient to take drug 30 minutes before traveling and to repeat dose before meals and at bedtime.
• Instruct patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Caution patient to avoid alcohol and sedative-hypnotics during therapy.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

Dramamine

(drăm′ə-mēn′)
A trademark for the drug dimenhydrinate.

Dramamine

a trademark now used for two different antiemetics, dimenhyDRINATE, and more recently meclizine (causes less sedation).
References in periodicals archive ?
I get a quick peek, but not an extended look because - wimp that I clearly am - I have now discovered that lying prone on a bench is a more effective palliative than the aforementioned Dramamine.
Core brands include Monistat women's health products, Nix lice treatment, Chloraseptic sore throat treatments, Clear Eyes eye care products, Compound W wart treatments, The Doctor's NightGuard dental protector, the Little Remedies and PediaCare lines of pediatric over-the-counter products, Efferdent denture care products, Luden's throat drops, Dramamine motion sickness treatment, BC and Goody's pain relievers, Beano gas prevention, Debrox earwax remover, and Gaviscon antacid in Canada.
While the technicians at Industrial Light & Magic have worked overtime to create a roiling squall that will have you reaching for some Dramamine, the film rarely manages to generate much in the way of suspense or terror.
At any rate, thanks to a sequence with camera work so jerky you practically need Dramamine to sit through it, he's a hero by episode's conclusion.
Today's over-the-counter drugs are a big step forward: Dramamine (dimenhydrinate), Bonine and Dramamine II (meclizine), the antihistamine Benadryl (diphenhydramine) and Peptobismal have all been used to varying degrees of success.
The next - after passage through a door, a metal detector and another door - the ambience changes so abruptly you feel the need for Dramamine.
For example, some of the more notable medicines which fall under the exclusions to this authorization include: Xanax, Vicodin, OxyContin, Percocet, Wellbuterin, Dramamine, Wellbuterin, Advil PM, Benadryl, and Oral Steroid Painkillers.
Some advice for the following 48 hours as the NBA launches into an accelerated signing period with all the speed, twists and turns of a Six Flags roller coaster: Remain seated, stay calm and maybe swallow a couple dramamine.
Dramamine round: Carin Kock played appropriately enough on the water-soaked fairways of Oakmont, bobbing up and down figuratively with her scorecard.
That Dramamine you take to calm your queasy tummy on choppy seas would be a distant memory inside the breakwater, where it's as flat as a lake.
Second, our clinicians report an increase in the abuse of over-the-counter substances -- such as DXM cough syrup, Dramamine and nitrous oxide -- that may not be captured by the survey results.