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Draize test

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Draize test
[drāz]
a controversial method of testing the toxicity of pharmaceutic and other products to be used by humans by placing a small amount of the substance in the eyes of rabbits. The eye-irritancy potential of a substance is considered a measure of the possible effect of the product on similar human tissues. The Draize in vivo test is recognized by the U.S. Food and Drug Administration as a reliable method of predicting the risk of new products to human eyesight, although alternative testing methods are being sought.


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Even supposedly simple targets for replacement, such as the Draize test for eye irritation, have proved difficult to model in vitro and progress through successful external validation despite major efforts by the European Centre for the Validation of Alternatives (ECVAM), industry trade associations, individual companies, and academia.
One commonly used procedure is the Draize Test, which is used to test household products for harmful chemicals.
The irritants depressed metabolism in test cells by amounts that closely parallel Draize test results.
 
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