Draize test


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Draize test

(drāz)
n.
A test to determine the degree to which a substance such as a cosmetic or pharmaceutical irritates human tissues, in which a small amount of the substance is applied directly in the eye of a rabbit, and the rabbit is then monitored.

Draize test

[drāz]
a controversial method of testing the toxicity of pharmaceutic and other products to be used by humans by placing a small amount of the substance in the eyes of rabbits. The eye-irritancy potential of a substance is considered a measure of the possible effect of the product on similar human tissues. The Draize in vivo test is recognized by the U.S. Food and Drug Administration as a reliable method of predicting the risk of new products to human eyesight, although alternative testing methods are being sought.
References in periodicals archive ?
According to the Johns Hopkins Center for Alternatives to Animal Testing (CAAT), a major protest campaign in the 1980s raised awareness among consumers and within the cosmetics industry about how harsh and inhumane the Draize Test could be for its unwitting subjects.
Another reason many companies are moving away from the Draize Test is that considerable information has already been yielded and recorded from past testing.
An extensive list of in vitro models that have been proposed as alternatives to the Draize test has been published (Bruner et al.
Weil and Scala (1971) determined that the numerical scores for the Draize test could not be reproduced in different laboratories.
He inspired individuals from more than 400 groups to dress in rabbit costumes and march outside Revlon's corporate offices in opposition to the company's use of the Draize test.
Six months later Revlon initiated a research program at Rockefeller University in New York City to look for alternatives to the Draize test.
The Draize test, which involves placing potential irritants into the eyes of rabbits to gauge potential reaction, has come under criticism in recent years.
2 million research program to prove the bovine lens test is as reliable as the Draize test.
The MultiCASE software comprises a model for eye irritation, developed from the results of 207 Draize tests.
The Draize Tests, which use live rabbits, however, have an error rate as high as 40 percent and are considered too costly and time consuming to use for optimizing product formulations.