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doxorubicin
(redirected from Doxorubicin-induced cardiomyopathy)

   Also found in: Wikipedia 0.04 sec.
doxorubicin /doxo·ru·bi·cin/ (dok?so-roo´bi-sin) an antineoplastic antibiotic, produced by Streptomyces peucetius, which binds to DNA and inhibits nucleic acid synthesis; used as the hydrochloride salt and as a liposome-encased preparation of the hydrochloride salt.
dox·o·ru·bi·cin (dks-rb-sn)
n.
An antibiotic obtained from the bacterium Streptomyces peucetius, used as an anticancer drug.

doxorubicin
an antineoplastic antibiotic, which binds to DNA and inhibits synthesis of nucleic acids and cell division. It is used intravenously to produce regression in various neoplastic conditions. The side-effects include bone marrow depression, alopecia and cardiac toxicity. Called also adriamycin. See also anthracycline antibiotic.

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The risk of doxorubicin-induced cardiomyopathy warrants regular follow-up of patients receiving combined chemotherapy regimens containing doxorubicin.
a cardioprotectant used in chemotherapy to counteract doxorubicin-induced cardiomyopathy.
Doxorubicin-induced cardiomyopathy and congestive heart failure is a well documented toxicity that appears to be dose-dependent with frequent occurrences as the cumulative dose exceeds 550 mg/[m.
 
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