doxorubicin /doxo·ru·bi·cin/ (dok″so-roo´bĭ-sin) an antineoplastic antibiotic, produced by Streptomyces peucetius, which binds to DNA and inhibits nucleic acid synthesis; used as the hydrochloride salt and as a liposome-encased preparation of the hydrochloride salt.
doxorubicin [dok″so-roo´bĭ-sin]
doxorubicin
dox·o·ru·bi·cin (d k s -r  b -sn)n. An antibiotic obtained from the bacterium Streptomyces peucetius, used as an anticancer drug. |
doxorubicin [dok″so-roo´bĭ-sin]
an antitumor antibiotic that binds to DNA, inhibits synthesis of nucleic acids, and inhibits cell division. It has one of the widest spectrums of antitumor activity of any antineoplastic agent and is administered intravenously as the hydrochloride salt. Side effects include bone marrow depression, alopecia, and cardiac toxicity; electroencephalogram monitoring is required during its administration. A liposome-encapsulated preparation of the hydrochloride salt is used in the treatment of Kaposi's sarcoma associated with acquired immunodeficiency syndrome (AIDS).
doxorubicin
an antineoplastic antibiotic, which binds to DNA and inhibits synthesis of nucleic acids and cell division. It is used intravenously to produce regression in various neoplastic conditions. The side-effects include bone marrow depression, alopecia and cardiac toxicity. Called also adriamycin. See also anthracycline antibiotic.
doxorubicin
Adriamycin Oncology An anthracycline antibiotic used for leukemias, lymphomas, sarcomas, solid tumors Adverse effects BM suppression, alopecia, vomiting, stomatitis, dose-dependent cardiomyopathy. See Chemotherapy.
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