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doxorubicin |
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doxorubicin /doxo·ru·bi·cin/ (dok?so-roo´bi-sin) an antineoplastic antibiotic, produced by Streptomyces peucetius, which binds to DNA and inhibits nucleic acid synthesis; used as the hydrochloride salt and as a liposome-encased preparation of the hydrochloride salt.
doxorubicin an antineoplastic antibiotic, which binds to DNA and inhibits synthesis of nucleic acids and cell division. It is used intravenously to produce regression in various neoplastic conditions. The side-effects include bone marrow depression, alopecia and cardiac toxicity. Called also adriamycin. See also anthracycline antibiotic. |
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To combat these odds, Marcus and his colleaues gave high-risk patients -- those with tumors larger than 10 centimeters and evidence of cancer spread -- five cycles of standard chemotherapy consisting of vincristine, cyclophosphamide and doxorubicin hydrochloride. The current standard first-line treatment for the aggressive form of NHL is the CHOP chemotherapy combination, comprising the drugs cyclophosphamide, doxorubicin hydrochloride, Oncovin(R) (vincristine) and prednisone. Anderson Cancer Center in Houston, Texas in which Onco TCS was used in combination with cyclophosphamide, doxorubicin hydrochloride, and prednisone. |
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