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down-regulation |
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down-regulation /down-reg·u·la·tion/ (doun reg-u-la´shun) a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent. down-regulation [doun reg-u-la′shun] a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually caused by long-term exposure to the agent. See also up-regulation . How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. The pYV plasmid-encoded Yop proteins have been implicated in lymphocyte suppression through downregulation of co-stimulatory molecules (13) and impairment of nitric oxide, tumor necrosis factor (TNF)-[alpha], and proinflammatory cytokine production (14). The idea behind this device is that patients will experience downregulation of the hyperstimulation that is associated with increased emotions and increased habituation. |
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