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down-regulation
(redirected from Downregulation)

   Also found in: Wikipedia 0.02 sec.
down-regulation /down-reg·u·la·tion/ (doun reg-u-la´shun) a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually due to long-term exposure to the agent.
down-regulation
[doun reg-u-la′shun]
a decrease in the number of receptors for a chemical or drug on cell surfaces in a given area, usually caused by long-term exposure to the agent. See also up-regulation .


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Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage.
The pYV plasmid-encoded Yop proteins have been implicated in lymphocyte suppression through downregulation of co-stimulatory molecules (13) and impairment of nitric oxide, tumor necrosis factor (TNF)-[alpha], and proinflammatory cytokine production (14).
The idea behind this device is that patients will experience downregulation of the hyperstimulation that is associated with increased emotions and increased habituation.
 
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