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Downregulation
(redirected from Downregulated)

    Also found in: Wikipedia 0.01 sec.
Downregulation
Cell biology The reduction of a cell’s response to a hormone or other ligand by internalizing its cognate receptor and degrading it within a coated pit; downregulation is a mechanism by which receptors respond to an excess of ligands
Genetics The decrease of a gene’s transcriptional machinery usually by a DNA-binding protein that acts on a regulatory region
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elegans, the fact that the two mammalian aquaporin glycerol-transporting channels are downregulated by insulin raises the possibility that glucose may have a life-span-shortening effect in humans, and, conversely, that a diet with a low glycemic index may extend human life span," the researchers said.
A 'spoonful of sugar' may reduce life expectancy by Asian News International
Considering the role of nuclear factor-kappaB (NF-kappaB) signaling pathway leading to many inflammatory molecules, it is an impressive breakthrough to discover NF-kappaB activity being downregulated in the prostate cancer cell.
Mastic through the ages by Gordin, Karina L. / Townsend Letter
PPT upregulated while DPN downregulated cyclin D1 and proliferating cell nuclear antigen (PCNA).
Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially ... by Life Extension
 
 
 
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