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Downregulation
(redirected from Down-regulate)

   Also found in: Wikipedia 0.01 sec.
Downregulation
Cell biology The reduction of a cell’s response to a hormone or other ligand by internalizing its cognate receptor and degrading it within a coated pit; downregulation is a mechanism by which receptors respond to an excess of ligands
Genetics The decrease of a gene’s transcriptional machinery usually by a DNA-binding protein that acts on a regulatory region


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But the exaggerated maternal inflammatory response in pre-eclampsia is due to a failure of the maternal immune system to down-regulate or tolerate its response to paternal antigens.
First, in vitro, docetaxel has been shown to down-regulate androgen receptor expression and PSA expression/secretion,[sup.
The body is then able to select those immune elements that it needs in order to up or down-regulate the autoimmune and inflammatory pathways.
 
 
 
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