Double Heterozygote

An organism in which there are 2 alleles for a particular trait, which is variably expressed
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There is also a combined variant, HbSC (known as sickle-hemoglobin C disease), or double heterozygote.
Arab] on the clinical severity of the disease, compared with the more frequently observed Hb S/C double heterozygote.
The last indeterminate sample had an unexpectedly low temperature transition and sequenced as the double heterozygote 1298AC, 1317TC (Fig.
The displacement of the double heterozygote was so great that it was distinguishable in all cases, but accurate detection of the single heterozygote was not achieved with all instruments.
The double heterozygote shows the greatest deviation from wild type because 2 mismatches are present within the PCR product.
The double heterozygote of two endothelin-1 gene polymorphisms (G8002A and -3A/-4A) is related to big endothelin levels in chronic heart failure.
HPLC detected all of the diseases detected by IEF except for one double heterozygote, in which the printed chromatogram was entirely normal (Table 2).
The parents are double heterozygotes for [alpha] and [beta]-thalassemia.
Patients who are double heterozygotes for the factor V Leiden and prothrombin G20210A, another high-incidence mutation in the white population, have a further increased risk for thrombosis.
In addition, by providing direct information about one defined haplotype, H-ARMS-PCR, may be useful for the identification of potentially ambiguous haplotypes in individuals who are double heterozygotes.
This test uses the expectation-maximization algorithm to resolve double heterozygotes into haplotypes and then applies a likelihood ratio test to determine whether the resolutions of haplotypes are significantly nonrandom, which is equivalent to testing whether there is statistically significant linkage disequilibrium between loci (18).