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dorzolamide

   Also found in: Wikipedia 0.02 sec.
dorzolamide /dor·zo·la·mide/ (dor-zo´lah-mīd) a carbonic acid anhydrase inhibitor, used as an antiglaucoma agent in the treatment of open-angle glaucoma and ocular hypertension; applied topically to the conjunctiva as the hydrochloride salt.
dorzolamide
a topical carbonic anhydrase inhibitor used in the treatment of glaucoma.

carbonic anhydrase inhibitors 
Drugs which inhibit the carbonic anhydrase enzyme in the ciliary epithelium of the ciliary body. This enzyme is essential for the formation of aqueous humour; its reduction results in a decrease in intraocular pressure. Those in use are sulfonamide derivatives. They are administered systemically (e.g. acetazolamide) or topically in the treatment of glaucoma. Examples: acetazolamide, brinzolamide, dichlorphenamide, dorzolamide.


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patents listed with the FDA which cover the combination of dorzolamide and timolol, the two active ingredients in COSOPT.
 
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