dopamine

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Related to Dopaminergic system: Noradrenergic system, Serotonergic system

dopamine

 [do´pah-mēn]
a compound produced by the decarboxylation of dopa; it is the direct precursor in the synthesis of norepinephrine and is also a neurotransmitter in the central nervous system. It is administered intravenously to correct hemodynamic imbalance in persons with shock because it increases blood pressure, especially systolic pressure, as well as urinary output; it is also used as a cardiac stimulant.

do·pa·mine (DM),

(dō'pă-mēn),
An intermediate in tyrosine metabolism and precursor of norepinephrine and epinephrine; neurotransmitter is the peripheral and central nervous systems; depletion of dopamine produces Parkinson disease.

dopamine

/do·pa·mine/ (-mēn) a catecholamine formed in the body by the decarboxylation of dopa; it is an intermediate product in the synthesis of norepinephrine, and acts as a neurotransmitter in the central nervous system. The hydrochloride salt is used to correct hemodynamic balance in the treatment of shock and is also used as a cardiac stimulant.

dopamine

(dō′pə-mēn′)
n.
A monoamine neurotransmitter formed in the brain by the decarboxylation of dopa and essential to the normal functioning of the central nervous system. A reduction in its concentration within the brain is associated with Parkinson's disease.

dopamine

[dō′pəmin]
a naturally occurring sympathetic nervous system neurotransmitter that is the precursor of norepinephrine. It is produced in the substantia nigra and transmitted to the putamen and caudate nucleus. It has an inhibitory effect on movement. A depletion of dopamine produces the symptoms of rigidity, tremors, and bradykinesia that are characteristic of Parkinson's disease. It is available as an intravenously injectable drug. Dopamine has potent dopaminergic, beta-adrenergic, and alpha-adrenergic receptor activity. See also dopamine hydrochloride.

dopamine

Neurology A catecholamine hormone and neurotransmitter essential to CNS activity; it is involved motor control, cognition, and reward; abnormal dopamine levels occur in Parkinson's disease, paranoia, memory and concentration defects; dopamine may modulate endorphin levels, altering perception of pain and pleasure; it restricts prolactin, affecting libido See Biogenic amine, Catecholamine, Indolamine, Serotonin.

do·pa·mine

(DM) (dō'pă-mēn)
An intermediate in tyrosine metabolism and precursor of norepinephrine and epinephrine.

dopamine

A monoamine NEUROTRANSMITTER and hormone with an adrenaline-like action. Dopamine is the principal neurotransmitter in the extrapyramidal system. It is formed in the brain from the amino acid tyrosine via dopa and the latter, in the form of levodopa is used to treat PARKINSON'S DISEASE. Dopamine is the precursor of noradrenaline. It is also concerned with mood, memory and food intake. Excess is associated with psychiatric disorders. Dopamine is converted into at least 30 other substances some of which are hallucinogenic. The drug is on the WHO official list.

dopamine

the decarboxylation product of DOPA. Formula: C8H11 O2 N.

Dopamine

A neurochemical made in the brain that is involved in many brain activities, including movement and emotion.

dopamine

a neurotransmitter, especially within the brain, in pathways related to the co-ordination of movement and to behaviour and emotion; deficiency of dopamine in the brain is associated with Parkinson's disease. Its secretion from the brain into the hypophysial portal blood vessels inhibits prolactin secretion from the anterior pituitary. Also, in the adrenal medulla it is a precursor of adrenaline and noradrenaline, and is itself released as a neurohormone.

dopamine

central nervous system neurotransmitter, found especially in substantia nigra of basal ganglia (i.e. caudate and lentiform nuclei) essential for normal movement; loss of dopamine transmission within substantia nigra is characteristic of parkinsonism (see Table 1)
Table 1: Effects of stimulation of alpha, beta and dopamine receptors
ReceptorActionStimulating drug
Alpha-1 (α1); postsynapticVasoconstriction; positive inotropism; antidiuresisAdrenaline +
Noradrenaline +++
Alpha-2 (α2); presynapticVasodilatation; inhibition of noradrenaline releaseAdrenaline +
Noradrenaline +++
Dopamine +
Alpha-2 (α2); postsynapticConstriction of coronary arteries; promotion of salt and water excretionAdrenaline +
Noradrenaline +++
Dopamine +
Beta-1 (β1); postsynapticPositive inotropism; chronotropism; renin releaseAdrenaline ++
Noradrenaline ++
Isoprenaline ++
Dopamine +
Beta-2 (β2); presynapticNoradrenaline release accelerated; positive inotropism; chronotropismAdrenaline +
Isoprenaline +++
Beta-2 (β2); postsynapticVasodilatation; relaxation of bronchial smooth muscleAdrenaline +
Isoprenaline +++
Dopamine1; postsynapticVasodilatation; diuresisDopamine ++
Dopamine1; presynapticInhibits noradrenaline releaseDopamine +

Plus signs indicate degree of effect.

dopamine (dōˑ·p·mēn),

n a neurochemical that supports fine motor activity, blood pressure, focus, inspiration, intuition, enthusiasm, and joy, among other functions.

do·pa·mine

(dō'pă-mēn)
An intermediate in tyrosine metabolism and precursor of norepinephrine and epinephrine.

dopamine

(dō´pəmēn´),
n a sympathomimetic catecholamine used in the treatment of shock, hypotension, and low cardiac output.

dopamine

a compound, hydroxytyramine, produced by the decarboxylation of dopa; an intermediate product in the synthesis of norepinephrine. It is a neurotransmitter in the central nervous system; administered intravenously to correct hemodynamic imbalance in shock syndrome.

dopamine agonist
used to terminate pregnancy. See bromocriptine, cabergoline.
dopamine β-hydroxylase
enzyme catalyzing the synthesis of norepinephrine from dopamine. A copper-containing mono-oxygenase requiring vitamin C (ascorbic acid).
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Environmental risk factors during early life and adolescence may interact with the dopaminergic system to influence alcohol intake.
Thus, acute pharmacological adjunctive treatment should consist of preferential blocking of postsynaptic NAc DA receptors (D1-D5), whereas long-term activation of the mesolimbic dopaminergic system should involve activation and/or release of DA at the NAc site.
Involvement of the serotonergic, noradrenergic and dopaminergic system in the antidepressant effect of FRA in FST
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Schapira, "Early dopaminergic support for the degenerating dopaminergic system per se provides significant long-term clinical benefit for PD patients,"22 leading to "a novel concept for neuroprotection, and that is simply to treat early rather than delay.
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There is substantial evidence for the involvement of the dopaminergic system in the development of schedule-induced polydipsia (for a review see Flores & Pellon, 2001).
Dopamine is a neurotransmitter, which activates dopamine receptors in brain, and disorders of this dopaminergic system affect movement control and cause a decline in neurocognitive functions [1, 2].
These results continue to support the idea that the brain dopaminergic system is altered in RLS and that the differences in the dopaminergic system are consistent with insufficient iron," Dr.
It is suggested that drugs which act on the dopaminergic system in the brain can be used to treat RLS, but there is no licence in the UK for the drugs to be used for the condition.