dopamine beta-monooxygenase

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do·pa·mine β-mon·o·ox·y·gen·ase

(dō'pă-mēn mon'ō-oks'i-jen-ās),
A copper-containing enzyme catalyzing oxidation of ascorbate and 3,4-dihydroxyphenylethylamine simultaneously by O2 to yield norepinephrine, dehydroascorbate, and water; a crucial step in catecholamine metabolism. The enzyme is stimulated by fumarate.
References in periodicals archive ?
Genetic mapping has suggested that people who experience disulfiram-induced dysphoria have a dominant mutation in a gene leading to the synthesis of dopamine beta-hydroxylase, a mutation that results in abnormally low enzyme levels.